干扰素敏感的造血原体可以动态改变生物体的免疫力
bioRxiv : the preprint server for biology
|May 7, 2024
概括
过渡性皮肤炎症触发I型干扰素 (IFN) 改变造血干细胞/原生细胞 (HSPC),影响全身免疫力. 这些改变的HSPC可以保护动脉样硬化,但会恶化流感的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 血液形成 血液形成 血液形成
- 炎症生物学 炎症生物学
背景情况:
- 组织受限的炎症可以深刻地影响系统免疫力.
- 将局部炎症与系统性免疫变化联系在一起的具体机制仍然不完全理解.
- 造血干细胞/原始细胞 (HSPCs) 是免疫反应的核心,但它们通过外周信号的调节是一个活跃的研究领域.
研究的目的:
- 阐明组织受限炎症重编程系统性宿主反应的机制.
- 调查I型干扰素 (IFN) 信号传导在炎症后调节造血干细胞/原生细胞 (HSPCs) 的作用.
- 为了确定IFN介导的HSPC改变对宿主免疫的功能后果.
主要方法:
- 利用小鼠皮肤炎症的分隔模型.
- 分析了系统性免疫反应,包括对动脉样硬化和流感病毒感染的结果的保护.
- 研究了IFNAR信号的作用,并采用了复合IFNα的管理.
- 进行了HSPC转移实验,以评估免疫表型的遗传性.
- 检查了染色质可访问性和原始细胞状态的长期变化.
主要成果:
- 皮肤炎症诱导HSPCs的I型IFN介导激活,导致显著的系统性免疫变化.
- 后炎症小鼠表现出对动脉样硬化的保护,但对流感感染的敏感性增加.
- IFNAR信号对于IFN介导的HSPC调制至关重要,IFNα的管理可以模仿这种调制.
- 通过采养转移后炎症的HSPCs成功地传递了免疫抑制表型.
- 在HSPC中IFN诱导的改变涉及持久的表观遗传变化和IFN响应状态的发展.
结论:
- 过渡性炎症,特别是I型IFN信号,对HSPC功能和全身免疫具有持久的影响.
- IFN调节的HSPC可以编程不同的系统性免疫结果,包括对不同疾病的易感性改变.
- 这些发现揭示了外围免疫信号形成长期造血干细胞功能和宿主防御的新途径.
更多相关视频
11:06Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
Published on: March 21, 2017
7.9K
06:12Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
Published on: March 7, 2022
3.5K
相关概念视频
01:01Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
01:19Multipotency of Hematopoietic Stem Cells
3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
01:23Cells of the Adaptive Immune Response
980
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
980
01:21Hematopoiesis
5.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.2K
01:40Cell-mediated Immune Responses
68.2K
Overview
68.2K
01:15Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K