听力功能缓和与年龄相关的大脑形态学变化在HCP老龄化队列中
Robert M Kirschen1, Amber M Leaver1
1Department of Radiology, Northwestern University, Chicago, IL, 60611.
bioRxiv : the preprint server for biology
|May 7, 2024
概括
听力损失加快了大脑的衰老,特别是在感官区域和心室. 保护听力可能有助于减少与年龄有关的神经退行和大脑结构变化.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 审计科学 审计科学
背景情况:
- 衰老与神经退行和听力损失有关.
- 听力损失对结构性大脑衰老的影响需要进一步调查.
研究的目的:
- 为了研究听力损失如何影响结构性大脑衰老.
- 为了确定听力障碍和与年龄相关的大脑变化之间的关系.
主要方法:
- 人类连接组项目衰老 (HCP-A) 数据的分析 (n=623).
- 使用了T1加权的MRI和Words in Noise (WIN) 值.
- 使用线性回归和Freesurfer进行大脑结构分析,控制年龄和纠正错误发现率.
主要成果:
- 听力损失 (较高的WIN值) 与与年龄相关的加速腹腔扩张和皮质恶化相关.
- 听力较差与感官区域和叶白质的皮质厚度降低有关.
- 在听力和认知能力较差的老年人中,观察到平海马区域的白质体积较低.
结论:
- 在衰老中保持听力与与年龄相关的大脑变化减少有关,特别是在中间叶.
- 良好的听力与听觉和感官区域的皮质组织的保存有关.
- 保护听力的干预措施可以减轻一些与年龄有关的神经退行变化.
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