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Updated: May 12, 2026

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从中选中开发杂小分子APOBEC3B抑制剂的开发

Katherine F M Jones1, Özlem Demir2, Mackenzie K Wyllie3

  • 1Department of Chemistry, University of Minnesota, Minneapolis, MN, USA.

bioRxiv : the preprint server for biology
|May 7, 2024
PubMed
概括

研究人员确定了APOBEC3B的新型小分子抑制剂,这是瘤突变和治疗耐药性的关键驱动因素. 这些化合物通过向APOBEC3B C终端域来开发新的癌症治疗方法.

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...