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Updated: Jun 27, 2025

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Taste Exam: A Brief and Validated Test
Published on: August 17, 2018
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全球研究苦药及其修饰剂的味道
Ha Nguyen1, Cailu Lin1, Katherine Bell1
1Monell Chemical Senses Center, Philadelphia PA, USA.
bioRxiv : the preprint server for biology
|May 7, 2024
概括
患者对苦味的感知因祖先而异,影响药物的味道. 遗传变异影响个人如何体验苦药和甜味剂,帮助未来的口味掩饰策略.
科学领域:
- 药物基因组学 药物基因组学
- 感官科学 感官科学
- 人类遗传学 人类遗传学
背景情况:
- 药物的苦味减少了患者的药物坚持.
- 在全球范围内存在对苦感知的个体差异.
- 了解这些差异对于改善药物配方至关重要.
研究的目的:
- 调查不同的祖先如何在药物和味道修饰剂中感知苦味.
- 为了将苦感知与遗传变异相关联.
- 为开发更好品味的药物提供信息.
主要方法:
- 来自欧洲和亚洲,南亚和非洲移民背景的338名成年人参与了这项研究.
- 参与者对五种药物和四种其他溶液的苦味强度进行了评分.
- 收集唾液样本进行基因定型,包括苦味受体基因 (TAS2R38).
主要成果:
- 对于两种药物 (阿莫迪亚奎因,甲) 和药物甜味剂混合物,苦味感知因祖先而异.
- 基因分析显示TAS2R38变异与甲酸苦味感知相关.
- 特定的基因型 (RIMS2,THSD4) 与糖的苦味感觉增加有关.
结论:
- 祖先和遗传因素显著影响药物苦味的感知.
- 研究结果强调需要个性化的方法来掩盖药品中的味道.
- 这项研究可以指导药物的配方,以改善患者在不同人群中的遵守.
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