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Updated: Jun 27, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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塞浦路斯:具有高强度和持久效果的催化细胞外向性蛋白质降解

Zachary R Crook1,2,3, Gregory P Sevilla1,2,3, Pamela Young2

  • 1Cyclera Therapeutics Inc, Seattle, WA 98115, USA. Present address of Z.R.C., G.P.S., and N.W.N.

bioRxiv : the preprint server for biology
|May 7, 2024
PubMed
概括

CYpHER技术提供了一种新的方法,通过利用pH取决于endolysosomal传递和回收利用向蛋白质降解 (TPD). 这种方法增强了药物的效力,并减少了治疗癌症等疾病的非目标风险.

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