功能网络中的性别差异是儿童精神病类经历的基础
Elvisha Dhamala1,2, Sidhant Chopra3,4, Leon Q R Ooi5,6,7,8,9
1Institute of Behavioral Sciences, Feinstein Institutes for Medical Research, Manhasset, USA.
bioRxiv : the preprint server for biology
|May 7, 2024
概括
年轻人的精神病类经历 (PLEs) 与大脑连接的差异有关,这些差异因性别而异. 了解这些特定于性别的神经生物学标志物对于早期心理健康干预至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 类似精神病的经历 (PLEs) 是类似于精神病的下值症状,在年轻人中很常见.
- PLEs与发育障碍有关,可能表明未来的心理健康问题.
- 关于PLE神经生物学的研究往往忽视了性别特异性的差异.
研究的目的:
- 调查童年PLE的特定性别的神经生物学基础.
- 确定与男性和女性PLE相关的功能性大脑网络连接的相似性和差异.
主要方法:
- 使用了来自ABCD研究的大样本 (n=5,260).
- 分析了与PLEs相关的功能网络连接.
- 在性别之间比较神经生物学关联.
主要成果:
- 发现性别之间的PLEs的重叠和独特的功能网络连接模式.
- 雌性表现出与皮层和非皮层连接分散的关联.
- 雄性表现出主要在边缘,顶,体内/运动和视觉网络中的关联.
结论:
- 儿童期PLE在男性和女性中具有明显的神经生物学相关性.
- 这些性别特异性标记表明精神病理学的早期跨诊断指标可能因性别而异.
- 强调在精神病学研究和临床实践中考虑性别的重要性.
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