在osimertinib诱导的肺炎后,成功地在没有同时使用皮质类固醇的情况下重新挑战 osimertinib
Taisuke Ito1, Kazuo Tsuchiya1, Rie Mori1
1Department of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Shizuoka City, Shizuoka, Japan.
Respiratory medicine case reports
|May 7, 2024
概括
奥西默提尼布可以在肺癌患者中引起肺炎,但重新挑战可能是安全的. 这一病例显示了肺部和脑脊髓转移的成功治疗,再次使用 osimertinib,而肺炎没有复发.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 药理学 药理学 是一个学科.
背景情况:
- 肺腺癌与EGFR外原19删除经常用 osimertinib 治疗.
- 奥西默提尼布可以诱导肺炎,这是一个严重的副作用.
- 勒普托门转移是晚期肺癌的一个具有挑战性的并发症.
研究的目的:
- 报告患有肺腺癌的患者患有奥西默蒂尼布诱导的肺炎病例.
- 描述肺炎解决后奥西默提尼布的成功再给药情况.
- 为了突出大脑和脑膜瘤转移的管理与重新挑战的 osimertinib.
主要方法:
- 一名60岁的妇女患有IVB期肺腺癌和EGFR外基因19缺失,接受了osimertinib治疗.
- 由于怀疑药物诱导的肺炎,Osimertinib的治疗被停止.
- 在肺炎消失后,奥西默提尼布被重新用于大脑和脑转移.
主要成果:
- 患者出现咳和双边磨砂玻璃不透明,诊断为奥西默提尼布诱导的肺炎.
- 肺炎在停止服用奥西默蒂尼布后消失.
- 重新服用奥西默蒂尼布成功治疗了大脑和膜内脏转移,在八个月内没有出现肺炎复发.
结论:
- 奥西默提尼布诱导的肺炎是一种可管理的副作用.
- 用osimertinib重复挑战可能是一个安全有效的策略,用于肺腺癌与EGFR突变,即使在肺炎.
- 通过重新服用 osimertinib.com 实现了勒普托门转移的成功治疗.
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