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皮质 - 杏仁体电路中的病理生理学和过度厌恶处理:寡干细胞和髓化的作用
Giulia Poggi1, Federica Klaus2,3, Christopher R Pryce1,4,5
1Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, CH-8008 Zurich, Switzerland.
Brain communications
|May 7, 2024
概括
压力通过大脑电路改变了情绪处理. 本综述比较了人类和动物研究前带带膜/中前额叶皮质-杏仁体电路及其在压力障碍中的髓化变化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 细胞生物学 细胞生物学
背景情况:
- 与压力相关的疾病涉及到改变的情绪处理,特别是负面刺激.
- 前带状皮质 (ACC) / 中间前额皮质 (mPFC) -杏仁体电路对于人类和动物的情绪处理至关重要.
- 这个电路的功能障碍与与压力有关的神经精神疾病有关.
研究的目的:
- 为了比较评估ACC/mPFC-杏仁体电路在物种间厌恶处理中的作用.
- 在人类压力障碍和动物压力模型中检查这些电路的结构和功能变化.
- 在与压力相关的条件下,研究这些电路内的寡细胞和髓化变化的研究.
主要方法:
- 对现有的人类和动物神经成像和细胞研究进行比较分析.
- 在厌恶处理中对ACC/mPFC-杏仁体电路功能的证据的审查.
- 检查细胞和分子变化,专注于寡细胞和髓.
主要成果:
- ACC/mPFC-杏仁体电路是人类和动物厌恶处理的组成部分.
- 这些电路在人类压力障碍 (减少) 和动物模型 (增加) 中显示了白质完整性的改变.
- 在压力障碍中,在这些电路中观察到寡细胞和髓化变化,尽管研究结果往往不一致.
结论:
- 在与压力相关的疾病中,ACC/mPFC-杏仁体电路对于处理厌恶刺激至关重要.
- 虽然结构和细胞变化很明显,但在ACC/mPFC-杏仁体电路中存在物种特异性差异.
- 需要进行进一步的研究,以确定寡基细胞系和髓化在压力障碍病理生理学中的因果作用.
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