性结肠炎相关的新生体通常含有不良预后的组织学成分,通过活检检测的检测能力较低
Ryoya Sakakibara1, Shinya Sugimoto1, Kaoru Takabayashi2
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Intestinal research
|May 7, 2024
概括
性结肠炎相关的新生体 (UCANs) 与差异化,签戒细胞或粘膜成分 (por/sig/muc) 显示出侵入性增加和生存率降低. 这些侵略性的UCAN亚型在术前活检中经常被遗漏,需要仔细的治疗规划.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 与散发性瘤相比,结肠炎相关的癌症表现出差异化腺癌,结环细胞癌和粘膜腺癌 (por/sig/muc) 的患病率更高.
- 这些组织学亚型与预后不佳有关,但它们在性结肠炎相关瘤 (UCANs) 中的特定侵入性和临床表现尚不清楚.
研究的目的:
- 为了确定 por/sig/muc 组件在 UCAN 中的流行率.
- 为了研究这种成分与瘤侵入性的关联.
- 为了澄清含有 por/sig/muc 组件的 UCAN 的临床组织学和内学特征.
主要方法:
- 追溯观察性研究.
- 包括在1997年至2022年期间被诊断患有性结肠炎相关的高度发育不良或腺癌的患者.
- 将患者划分为组,根据 por/sig/muc 组件的存在或不存在来划分.
主要成果:
- 35名患者接受了含por/sig/muc成分的UCAN,66名患者没有UCAN.
- 与管状组相比,por/sig/muc组的5年生存率 (67%) 显著低于管状组 (96%),与晚期和深入入侵有关.
- 在手术前的活检中,仅在40%的病变中检测到por/sig/muc成分,尽管其患病率随瘤阶段的增加而增加.
结论:
- 具有 por/sig/muc 组件的 UCAN 具有深入入侵的倾向,并且在手术前经常被诊断不足.
- 内镜师必须认识到,UCAN可能含有未被识别的por/sig/muc组件.
- 仔细考虑最佳治疗策略对于这些侵袭性瘤至关重要.
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