Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
145
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

136
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
136
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

126
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
126
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

89
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
89
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

166
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
166

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Impact of BECLIN1 haploinsufficiency on goblet cell function and susceptibility to colitis.

Cell death & disease·2026
Same author

Reply.

Gastroenterology·2026
Same author

Rethinking the dose: A Bayesian meta-analysis of infliximab intensification in acute severe ulcerative colitis.

Inflammatory bowel diseases·2026
Same author

Quality of healthcare delivery in inflammatory bowel disease pregnancy: a scoping review.

Inflammatory bowel diseases·2026
Same author

Monocyte Distribution Width Differentiates Bacterial Enterocolitis from Acute Severe Ulcerative Colitis in the Emergency Department.

Digestive diseases and sciences·2026
Same author

Reply.

Gastroenterology·2026

相关实验视频

Updated: Jun 27, 2025

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

9.3K

使用预测模型定义急性严重性结肠炎的管理策略:一个模拟建模研究.

Danny Con1, Peter De Cruz1,2

  • 1Department of Gastroenterology, Austin Health, Heidelberg, Australia.

Intestinal research
|May 7, 2024
PubMed
概括

预测模型可以指导急性严重性结肠炎 (ASUC) 耐受性治疗. 优化的策略通过对患者进行先进疗法的分层来显著降低胆管切除率,从而改善结果.

科学领域:

  • 胃肠病学 胃肠病学
  • 临床信息学 临床信息学
  • 计算生物学 计算生物学

背景情况:

  • 急性严重性结肠炎 (ASUC) 管理需要改进的策略,以最大限度地减少对因弗力西马布无反应的患者的结肠切除风险.
  • 标准的因弗利克西马布诱导疗法留下了显著的残留胆管切除风险.

研究的目的:

  • 评估ASUC预测模型驱动的管理策略的有效性.
  • 评估不同预测模型准确度对胆管切除率的影响.

主要方法:

  • 一项模拟研究模拟了5000名患有类固醇耐药ASUC的患者,他们接受了因弗利西马布诱导.
  • 预测模型被用于风险分层患者进行升级治疗.
  • 主要终点是3个月的胆管切除率.

主要成果:

  • 一个没有预测建模的基准场景显示了23%的胆管切除率.
  • 使用90%AUC预测模型的优化策略将胆管切除术减少到8% (65%的风险降低).
  • 一个不太准确的模型 (80%的AUC) 将胆管切除术减少到15% (35%的风险降低),突显了对模型准确性和治疗疗效的依赖.

结论:

关键词:
进行大肠切除术 (colectomy).炎症性肠道疾病 炎症性肠道疾病这就是Infliximab.瘤亡因子-阿尔法

更多相关视频

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

879
Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
00:08

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.0K

相关实验视频

Last Updated: Jun 27, 2025

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

9.3K
Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
06:24

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

879
Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
00:08

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.0K
  • 这项研究表明了基于模拟预测模型的策略在ASUC管理中的潜力.
  • 准确的预测模型对于优化治疗升级和降低胆管切除率至关重要.
  • 未来的研究应该整合模拟研究,用于ASUC的预测模型开发.