安德罗格拉福利德的潜在抗牛皮作用:对局部皮质类固醇进行比较研究
Indira Dharmasamitha1, Luh Made Mas Rusyati1, Dyah Kanya Wati2
1Department of Dermatology, General Hospital Prof. Dr. I.G.N.G Ngoerah, Faculty of Medicine, Udayana University, Denpasar, Indonesia.
概括
来自Sambiloto的andrographolide (AP) 通过减少炎症显示出治疗牛皮的潜力. 一种AP (0.1%) 的乳膜配方在PASI分数和皮肤体内皮肤状况显著改善.
科学领域:
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
- 计算化学计算化学
背景情况:
- 安德罗格拉福利德 (AP) 是一种Sambiloto衍生的抗炎化合物,可以抑制关键的炎症标志物,如NF-κB,TNF-α和IL-6.
- 分子对接表明,AP对NF-κB受体的结合亲和力比德克萨梅他更高,表明它对牛皮治疗的潜力.
研究的目的:
- 与局部皮质类固醇相比,评估Sambiloto公司Andrographolide (AP) 在治疗牛皮方面的有效性.
- 为了研究AP乳膜配方的抗皮病活性.
主要方法:
- 这项研究涉及薄层染色学 (TLC) 用于AP含量分析,乳膜制剂,分子对接模拟,体皮肤毒性评估和体内抗牛皮病疗效测试.
- 在体内评估包括监测牛皮病区域和严重性指数 (PASI) 评分,测量分子参数 (IL-6,IL-17,VEGF,TNF-α) 和评估七天干预期内的基因病理发现.
主要成果:
- 分子对接表明andrographolide具有与IL-6,NF-kB和TNF-α的高结合亲和力,与皮质类固醇可比,具有类似的残留相互作用概况.
- 在体内研究表明,在干预后,最终的PASI得分 (p=0.017),红色 (p=0.017),缩放 (p=0.040),厚度 (p=0.023),整体病原学得分 (p=0.037) 和质层得分 (p=0.018) 在统计学上显著改善.
结论:
- 0.1%的安德罗格拉福利德 (AP) 乳液配方有效地减少了关键的炎症标志物,这对于控制牛皮的进展至关重要.
- AP显示出作为治疗牛皮的局部治疗的巨大潜力,为传统疗法提供了替代或辅助疗法.
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