和多醇基物质改变先天免疫功能:证据和数据缺口
Drake W Phelps1,2,3, Ashley M Connors1,2,3,4,5, Giuliano Ferrero1,2
1Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA.
和多基基物质 (PFAS) 是广泛存在的环境污染物. 本综述综合了目前关于PFAS对先天免疫力影响的文献,揭示了物种间潜在的干扰.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
背景情况:
- 由于它们在工业过程和消费品中广泛使用,和多基物质 (PFAS) 是普遍存在的,持久的环境污染物.
- 现有的审查主要集中在适应性免疫系统对PFASs的反应上,经常忽视对先天免疫力的影响.
- 由于PFAS的持续性和无处不在,因此需要全面了解它们对所有免疫系统组件的毒理作用.
研究的目的:
- 审查和综合当前关于PFASs对人类,实验模型和野生动物天生的免疫力影响的文献.
- 确定和讨论PFAS调节先天免疫功能的已知机制.
- 突出研究缺陷,并为未来关于PFAS和免疫健康的研究提供建议.
主要方法:
- 关于PFAS和先天免疫力的科学出版物的文献综述.
- 包括来自人类研究,实验动物模型和野生动物暴露评估的数据.
- 对PFAS免疫调节作用报告的机制的分析.
主要成果:
- 关于PFAS对先天免疫力的影响的数据往往含糊不清,表明复杂的相互作用.
- 已经证明,暴露于PFAS会扰乱各种物种的先天免疫系统.
- 机制包括破坏细胞信号通路,代谢过程和组织水平的影响.
结论:
- 天生的免疫系统容易受到PFAS暴露的干扰.
- 需要进一步的研究来阐明PFAS诱导的先天性免疫毒性的常见机制和途径.
- 这些发现强调了在对环境和生物健康的风险评估和管理策略中考虑先天性免疫的重要性.
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