甲状腺功能障碍和排泄性与年龄相关的黄斑变性 - 一个纵向的全国性基于注册表的队列研究
Lena Boulakh1, Jonas L Isaksen2, Henrik Enghusen Poulsen3,4,5
1Department of Ophthalmology, Rigshospitalet - Glostrup, Glostrup, Denmark.
Acta ophthalmologica
|May 7, 2024
概括
甲状腺功能低下症和甲状腺功能过高症都会增加患出血性与年龄有关的黄斑变性 (AMD) 的风险. 这项研究强调了潜在的公共卫生影响,强调需要进一步研究将甲状腺功能障碍与AMD连接在一起的潜在机制.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 与年龄相关的黄斑变性 (AMD) 是老年人视力丧失的主要原因.
- 甲状腺功能障碍和排泄性AMD之间的关系在很大程度上仍未被探索.
研究的目的:
- 为了研究甲状腺功能障碍 (甲状腺功能低下和甲状腺功能过高) 与外泄性AMD的发展之间的关联.
- 为了确定甲状腺疾病是否代表出血性AMD的危险因素.
主要方法:
- 在丹麦 (2008-2018) 进行了一项纵向的全国性队列研究,其中包括50-100岁的居民.
- 甲状腺功能障碍是通过连续处方甲状腺或抗甲状腺药物来确定的.
- 露出性AMD是由ICD诊断和抗VEGF治疗代码定义的.
主要成果:
- 该研究包括超过200万个人,甲状腺功能低下症和甲状腺功能过高症分别影响2.8%和1.6%.
- 甲状腺功能低下症 (HR: 1.17) 和甲状腺功能过高症 (HR: 1.23) 两种症状都显著与患出血性AMD的风险增加有关.
- 这种关联在老年人群中更为明显.
结论:
- 这是第一个全国性的研究,表明甲状腺功能低下和甲状腺功能过高以及排泄性AMD风险增加之间存在显著联系.
- 这些发现表明,鉴于AMD的流行程度,可能会对公众健康产生影响.
- 需要进一步的研究来阐明这种关联背后的生物学机制.
关键词:
在这个过程中,AMD是AMD.排泄性AMD是一种AMD.甲状腺功能过强症 甲状腺功能过强症甲状腺功能低下症 甲状腺功能低下症系统性疾病是一种系统性疾病.甲状腺疾病是一种甲状腺疾病.甲状腺功能障碍 甲状腺功能障碍更多相关视频
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