[在SARS-CoV-2恢复后长期肺损伤的临床和形态特征]
G E Baimakanova1, M Samsonova1,2, A L Chernyaev2,3,4
1Loginov Moscow Clinical Scientific Center.
Terapevticheskii arkhiv
|May 7, 2024
概括
在SARS-CoV-2感染后持续的呼吸道症状不是由于真正的肺纤维化. 观察到的肺部变化反映了正在进行或解决的炎症和感染,而不是痕.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- 在SARS-CoV-2感染后报告了持续的呼吸道症状和肺部异常.
- 潜在的病理,特别是肺纤维化,需要进一步调查.
研究的目的:
- 为了研究肺组织的临床和组织学特征,患者有持续的SARS-CoV-2后呼吸道症状.
- 为了确定SARS-CoV-2感染后是否存在真正的肺纤维化.
主要方法:
- 一组15名患有SARS-CoV-2后持续症状的患者接受了包括成像,肺功能测试和实验室分析在内的全面评估.
- 通过肺活检 (冷活检或开放活检) 和纤维支气管镜检查获得了肺组织和支气管支气管洗样本.
- 分析包括细胞组成,病原体检测 (SARS-CoV-2,疹病毒,结核菌菌,细菌,真菌) 和炎症标志物.
主要成果:
- 在SARS-CoV-2感染后患有持续呼吸道症状的患者中,没有发现真正肺纤维化症的证据.
- 观察到的肺组织变化与活跃或消失的感染和炎症一致.
结论:
- 真正的肺纤维化不是SARS-CoV-2感染后持续的呼吸道症状的一个特征.
- 这些患者的肺部异常归因于正在进行的炎症和感染过程.
相关概念视频
COPD: Pathogenesis and Clinical Features
263
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
263
Pneumonia II: Pathophysiology
260
The pathophysiology of pneumonia involves the following steps:
260
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
Pulmonary Cycle: Exhalation
1.6K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.6K
Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K


