与年龄相关的睡眠变化及其对精神分裂症老年人的认知衰退的影响:批判性审查
Bengi Baran1,2,3, Ellen E Lee4,5
1Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.
Schizophrenia bulletin
|May 7, 2024
概括
精神分裂症的认知衰退随着年龄的增长而恶化. 解决睡眠障碍,特别是阻塞性睡眠呼吸暂停 (OSA),可能有助于改善精神分裂症老年人的记忆和认知能力.
科学领域:
- 神经科学是一个神经科学.
- 睡眠科学 睡眠科学
- 精神病学是一个精神病学.
背景情况:
- 认知障碍是精神分裂症的一个主要挑战,随着年龄的增长而加剧.
- 非快速眼动 (NREM) 睡眠振荡,如子和缓慢的振荡,对于记忆巩固至关重要.
- 在精神分裂症患者 (PLWS) 中观察到NREM睡眠振荡和它们的协调减少,并预测记忆缺陷.
研究的目的:
- 审查PLWS中关于衰老,阻塞性睡眠呼吸暂停 (OSA) 和NREM睡眠振荡的文献.
- 探索NREM睡眠中断对老年PLWS认知衰退的影响.
- 调查OSA作为该人口认知缺陷的贡献因素的作用.
主要方法:
- 对已发表的研究进行了叙述性审查.
- 文献搜索侧重于PLWS中的衰老,OSA和NREM睡眠振荡.
- 对睡眠电路和精神分裂症现有研究的分析.
主要成果:
- 对于螺杆生成至关重要的thalamocortical反环,在精神分裂症中显示出超连接性.
- 老年PLWS特别容易受到OSA的影响,这进一步损害了NREM睡眠电路.
- 在老年PLWS中,OSA往往被诊断不足和治疗不足,导致认知结果恶化.
结论:
- 有必要研究老年PLWS的NREM睡眠.
- 在老年PLWS中识别和治疗OSA可以缓解认知衰退.
- 针对睡眠障碍提供了一个潜在的策略,以预防老化精神分裂症患者的认知缺陷.
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