患有重大血液恶性病的老年患者中心血管死亡的长期风险:来自SEER数据库的基于人口的队列研究
Hanqing Zhang1,2, Minghao He2,3, Peng Zhang2,3
1Guangzhou University of Chinese Medicine, Guangzhou, China.
概括
患有血液性恶性瘤的老年患者面临心血管疾病 (CVD) 死亡的风险明显更高. 长期的心血管风险管理与这些患者的癌症治疗一起至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
背景情况:
- 心血管疾病 (CVD) 是老年人关心的一个关键问题.
- 血液恶性瘤 (HM) 在老年人群中很常见.
- 在老年患者中,HM和心血管疾病风险之间的相互作用需要研究.
研究的目的:
- 为了确定与心血管疾病相关的死亡风险,在老年患者中诊断出主要的血液性恶性瘤.
- 将HM患者的心血管疾病死亡率与普通老年人群进行比较.
主要方法:
- 利用监测,流行病学和最终结果数据库对103,102名老年患者进行了HM (1975-2018).
- 雇员 细灰分区危险回归,标准化死亡率 (SMR) 和绝对超额风险 (AER) 进行风险评估.
- 分析了心血管疾病相关死亡比例和累积死亡率,平均随访时间为2.7年.
主要成果:
- 与心血管疾病相关的死亡是老年HM患者死亡的第二大原因,仅次于原发性恶性瘤.
- 与普通老年人群相比,老年HM患者对心血管疾病,心脏病和脑血管疾病的SMR和AER显著更高.
- 特定的HM类型 (例如,霍奇金淋巴瘤I/II阶段) 和患者年龄组 (患有慢性淋巴细胞白血病的≥85岁) 显示,随着时间的推移,心血管疾病死亡率超过了原发性恶性病.
结论:
- 患有HM的老年患者面临更高的长期心血管风险.
- 综合性心血管风险管理对于老年心血管疾病患者至关重要.
- 积极的管理策略应针对这一人口群中的高风险个人.
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