临床特征,成像和COVID-19持续性呼吸障碍患者的肺功能:一个回顾性观察队列研究
Ravi Manglani1, Moshe Fenster2, Theresa Henson3
1Division of Pulmonary and Critical Care, Sutter Gould Medical Foundation, Modesto, California. ravi.manglani@sutterhealth.org.
概括
长期COVID幸存者持续呼吸短促往往显示肺功能减弱. 异常的CT扫描与年龄较大,住院和下肺功能测试有关,包括强迫生命能力 (FVC).
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 后COVID条件 后COVID条件
背景情况:
- 有限的医学文献存在于长期COVID幸存者的肺功能.
- 持久性呼吸不良是长期COVID患者的常见症状.
研究的目的:
- 为了调查症状长期COVID患者的肺功能和临床特征.
- 确定与这些患者异常肺部成像相关的因素.
主要方法:
- 患有COVID-19后持续性呼吸障碍的患者在专门诊所进行了评估.
- 评估包括肺功能测试 (PFT),胸部计算机断层扫描 (CT) 和临床评估.
- 随着时间的推移,对所有参与者进行了随访.
主要成果:
- 不正常的CT成像在老年患者和以前因COVID-19住院的患者中更为普遍.
- 患有异常CT扫描的患者在第一秒内强制呼出的体积,强制生命能力 (FVC),肺总容量和一氧化碳的扩散能力的测量值显著降低.
- 多变量回归确定了FVC和体重指数,先前住院和糖尿病之间的关联.
结论:
- 长期COVID患者的异常肺部CT发现与特定的临床特征相关.
- 肺功能减弱,特别是FVC,与BMI,住院病史和糖尿病等因素有关.
- 进一步的长期研究是必要的,以充分了解长期COVID的预后和风险因素.
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