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Updated: Jun 27, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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CDK4 / 6 抑制剂:魔鬼在细节中

Tara Magge1, Sneha Rajendran1, Adam M Brufsky1

  • 1Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.

Current oncology reports
|May 7, 2024
PubMed
概括

循环素依赖性激酶4/6抑制剂 (CDK4/6i) 是HR+/HER2-乳腺癌的标准. 虽然有效,但毒性和成本限制使用,最佳时机需要进一步研究.

关键词:
这是一种CDK4/6抑制剂.内分泌耐药性 内分泌耐药性内分泌疗法是一种内分泌疗法.激素受体阳性乳腺癌是什么有针对性的治疗方法.

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