艾滋病毒对赞比亚高血糖和活跃结核病的关联的影响,一个病例控制研究
Sarah Lou Bailey1,2, Sian Floyd3, Maina Cheeba-Lengwe4
1LSHTM TB Centre and Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK. sarah-lou.bailey@nhs.net.
Journal of epidemiology and global health
|May 7, 2024
概括
总的来说,高血糖症与卢萨卡的活跃结核病没有联系. 然而,艾滋病毒显著改变了这种关联,在患有这两种疾病的个体中观察到更高的风险,特别是那些有涂抹/Xpert阳性结核病的人.
科学领域:
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 高血糖是众所周知的各种感染的危险因素.
- 结核病 (TB) 仍然是一个重大的全球卫生挑战,特别是在撒哈拉以南非洲.
- 高血糖,艾滋病毒和活跃结核病之间的相互作用需要进一步研究.
研究的目的:
- 在赞比亚卢萨卡调查高血糖和活跃结核病之间的关联.
- 为了确定人类免疫缺陷病毒 (HIV) 是否修改了这种关联.
主要方法:
- 在赞比亚卢萨卡进行了一项病例控制研究.
- 参与者包括新诊断的成年结核病例和人口对照.
- 血糖过高是通过随机血糖 (RBG) 水平和通过血清学评估HIV状态来评估的. 使用多变量逻辑回归.
主要成果:
- 过高血糖的患病率 (RBG ≥11.1 mmol/L) 在结核病患者 (1.4%) 和对照患者 (1.5%) 中相似.
- 总的来说,高血糖和活跃结核病 (aOR=1.60) 之间没有发现显著的关联.
- 然而,观察到艾滋病毒显著影响修改 (p=0.042),与艾滋病毒阳性个体 (aOR=5.47) 相比,与艾滋病毒阴性个体 (aOR=1.17) 相比,艾滋病毒阳性个体的相关性更强.
- 对于涂抹/Xpert阳性结核病 (aOR=2.97) 也注意到了这种关联.
结论:
- 虽然整体高血糖症与活跃结核病无关,但艾滋病毒显著改变了这种关系.
- 这些发现表明,艾滋病毒感染的高糖血症个体可能会增加活跃结核病的风险.
- 区分糖尿病和压力引起的高血糖是理解这些复杂相互作用的关键.
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