间歇性肺部疾病和渐进性肺纤维化:一个世界贸易中心队列20年纵向研究
Krystal L Cleven1, Rachel Zeig-Owens1,2,3, Alexandra K Mueller1,2
1Department of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Lung
|May 7, 2024
概括
世界贸易中心 (WTC) 暴露与间歇性肺部疾病 (ILD) 有关,在9/11之后的流行率更高. 年龄,吸烟和GERD是ILD和渐进性肺纤维化 (PPF) 的危险因素.
科学领域:
- 肺部医学 肺部医学
- 环境健康 环境健康
- 流行病学 流行病学
背景情况:
- 世界贸易中心 (WTC) 暴露与阻塞性呼吸道疾病和沙尔科毒症有关.
- 有限的研究存在于非沙尔科毒症间歇性肺病 (ILD) 的发病率和进展后WTC暴露.
- ILD可能导致渐进性肺纤维化 (PPF).
研究的目的:
- 估计纽约市消防局 (FDNY) WTC健康计划队列中非沙尔科毒性ILD的发生率和进展情况.
- 为了确定与ILD发育和在WTC暴露后的进展相关的风险因素.
主要方法:
- 一项对14525名没有先前存在ILD的FDNY响应者的纵向研究.
- 估计ILD发病率和流行率,标准化为美国2014年人口.
- 普森回归模型对ILD的风险因素,包括WTC暴露和强迫生命能力 (FVC).
主要成果:
- 在14525名受访者中,80名 (0.55%) 患有ILD.
- 年龄,吸烟和胃食道逆流性疾病 (GERD) 与发生ILD有关;FVC没有.
- 渐进性肺纤维化 (PPF) 发生在40 (50%) 的ILD病例中,死亡率更高.
结论:
- 在9/11事件后,ILD的患病率是一般人口的两倍多.
- 年龄,吸烟和GERD被确定为ILD和PPF的危险因素.
- 肺功能测试可能无法确定在WTC暴露后面临ILD或PPF风险的个体.
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