在康复的COVID-19患者中,角膜肌瘤分析和相关的眼部表现
Yuke Huang1,2,3,4, Taiwei Chen1,2,3,4, Xi Chen1,2,3,4
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Tianhe District, Guangzhou, China.
Investigative ophthalmology & visual science
|May 7, 2024
概括
严重急性呼吸道综合征冠状病毒-2 (SARS-CoV-2) 暂时改变角膜层,影响COVID-19后的神经长度和光密度. 这些变化没有影响折射手术的结果,确保康复后的安全性和有效性.
科学领域:
- 眼科医生 眼科 眼科
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 角膜拥有受体 (CD147,ACE2),使其易受SARS-CoV-2的感染.
- 了解COVID-19后的角膜变化对于患者管理和折射手术结果至关重要.
研究的目的:
- 评估SARS-CoV-2对角膜层状瘤特征和眼部表现的影响.
- 为了评估COVID-19后康复患者的折射性手术结果.
主要方法:
- 来自康复的COVID-19患者和健康对照者的角膜晶片被分析.
- 用Pentacam HR,OCT和光学显微镜测量角膜光学密度,上皮厚度和内皮参数.
- 免疫反应,包括IL-6水平,以及树皮神经形态在各种恢复时间进行了评估.
主要成果:
- 在康复后的角膜镜片中检测到SARS-CoV-2残留物和免疫反应 (升高的IL-6).
- 角膜支柱神经的长度和视觉密度在感染后暂时增加,在135天后恢复正常.
- 表皮厚度保持一致,折射手术 (SMILE) 的结果没有受到影响.
结论:
- SARS-CoV-2 诱导角膜 stromal 形态和功能的短暂变化.
- 这些发现支持在COVID-19后期折射手术的安全性,并为角膜健康管理提供信息.
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