肝脏侧腔内皮细胞通过IV型原蛋白驱动的侧腔内皮重塑,促进门脉高血压

相关实验视频

Updated: Jun 27, 2025

A Standardized Method for the Analysis of Liver Sinusoidal Endothelial Cells and Their Fenestrations by Scanning Electron Microscopy
08:38

A Standardized Method for the Analysis of Liver Sinusoidal Endothelial Cells and Their Fenestrations by Scanning Electron Microscopy

Published on: April 30, 2015

14.5K

Can Gan1,2, Usman Yaqoob2, Jianwen Lu2,3

  • 1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.

JCI insight
|May 7, 2024
PubMed
概括

由肝脏侧腔内皮细胞 (LSECs) 生产的IV型原蛋白 (COL4) 通过促进侧腔重塑,驱动肝纤维化和门性高血压. 在LSEC中准COL4可以缓解这些严重的并发症.

关键词:
细胞生物学 细胞生物学原蛋白是一种原蛋白.内皮细胞是内皮细胞.肝病学 肝病学是一种肝病学.

更多相关视频

Isolation and Characterization of Mouse Primary Liver Sinusoidal Endothelial Cells08:22

Isolation and Characterization of Mouse Primary Liver Sinusoidal Endothelial Cells

Published on: December 16, 2021

6.5K
In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion12:35

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

Published on: November 10, 2011

19.0K

相关概念视频

Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
738
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
2.2K
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
Hepatic Portal System01:21

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
1.2K
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
111