评估尼古丁固态同位素对尼古丁袋滥用责任的作用:一个随机交叉试验
Brittney Keller-Hamilton1,2, Hayley Curran2, Mahmood Alalwan2
1Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA.
概括
口服尼古丁袋 (ONP) 含有高S-尼古丁含量,可提供比拉塞米版本更高的血尼古丁度. 虽然主观吸引力是相似的,但需要进一步的研究来了解ONP的监管特征.
科学领域:
- 尼古丁的药理动力学和产品吸引力研究.
- 烟草减少危害的战略. 烟草减少危害的战略.
- 公共卫生政策和对新型尼古丁产品的监管.
背景情况:
- 许多口服尼古丁袋 (ONP) 使用合成尼古丁,即S-尼古丁和R-尼古丁的种族混合物.
- 烟草衍生的尼古丁主要是S-尼古丁 (>99%),使得R-尼古丁对人类的影响在很大程度上是未知的.
- 这项研究旨在比较尼古丁暴露和高S-尼古丁含量和种族尼古丁的ONP之间的吸引力.
研究的目的:
- 为了比较含有主要是S-尼古丁的口服尼古丁袋 (ONP) 与种族尼古丁之间的全身尼古丁暴露和产品吸引力.
- 根据立体同位素组成,研究尼古丁吸收的药理学差异.
- 评估用户报告的产品吸引力和与ONP中不同尼古丁立体异构体相关的戒断缓解.
主要方法:
- 一项涉及18名成年吸烟者的随机交叉研究,比较了三种3毫克冬绿味道的ONPs.
- 参与者在12小时尼古丁戒断后使用了ONP,在多个时间点测量了血尼古丁水平,长达90分钟.
- 使用后评估了产品的吸引力和戒断缓解,ONP被分类为主要含有S-尼古丁 (>99%的S-尼古丁) 或种族 (50:50的S-和R-尼古丁).
主要成果:
- 主要含有S-尼古丁的ONP与种族尼古丁ONP相比,在15到90分钟内产生显著更高的血尼古丁度.
- 血最大尼古丁度与S-尼古丁ONP (9.9 ng/mL) 相比,与种族ONP (5.7 ng/mL) 相比,在S-尼古丁ONP (9.9 ng/mL) 中大大增加.
- 这两种ONP类型的产品喜好和戒断缓解是可比的,尽管S-尼古丁ONP报告了更多的不良影响.
结论:
- 口服尼古丁袋主要含有S-尼古丁,导致系统尼古丁暴露率高于含有种族尼古丁的尼古丁袋.
- 尽管具有相似的主观吸引力,但含有高S-尼古丁的ONP可能由于尼古丁输送的增强而成为更有效的香烟替代品.
- 进一步研究其他ONP特征,如香料和自由基尼古丁含量,对于制定有效的监管政策至关重要.
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