在创伤记忆中量化创伤后应激障碍症状,使用可解释的呼吸系统变异性标记
概括
研究人员发现了在创伤记忆中测量呼吸模式 (呼吸模式变化或RPV) 的新方法. 在创伤回忆期间增加RPV与创伤后应激障碍 (PTSD) 症状有关.
科学领域:
- 心理生理学 心理生理学
- 创伤研究 创伤研究
- 呼吸系统医学 呼吸系统医学
背景情况:
- 创伤后应激障碍 (PTSD) 的特点是过度兴奋,对与创伤相关的记忆的战斗或逃跑反应加剧.
- 虽然理论上说过度兴奋会影响呼吸模式 (呼吸变化),但缺乏将其与人类PTSD症状联系起来的定量标志物.
研究的目的:
- 定义呼吸模式变化 (RPV) 的可解释标志物.
- 为了调查这些RPV标记在创伤性记忆回忆过程中是否发生变化.
- 确定RPV是否与PTSD症状严重程度相关,并在PTSD患者和对照人群之间存在差异.
主要方法:
- 156名越南时代的双胞胎退伍军人接受了创伤回忆协议.
- 呼吸和心电图数据被用来量化RPV使用四分位数范围.
- 在回忆期间的RPV变化 (∆RPV) 与基线相比较,与PTSD症状相关;对内双胞胎分析控制了共享因素.
主要成果:
- 在创伤性记忆回忆期间RPV显著增加 (p < .001).
- 在召回期间RPV (∆RPV) 的变化与PTSD症状严重程度正相关 (p < .05).
- 与暴露于创伤的对照人群相比,患有PTSD的患者的∆RPV显著更高 (p < .05).
结论:
- 这项研究引入了新的RPV标志物,在创伤后应激障碍中对创伤记忆有反应.
- 这些标记物与PTSD症状严重程度有显著的相关性.
- 这些发现表明RPV可以作为PTSD中过度兴奋的定量指标.
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