胆结石作为疑似急性酒精性胰腺炎的原因:观察性多中心研究
Noor J Sissingh1,2, Fleur E M de Rijk2,3, Hester C Timmerhuis2,4
1Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.
The British journal of surgery
|May 7, 2024
概括
胆结石存在于近20%的酒精性胰腺炎患者中,并增加了复发风险. 胆囊切除术可以减少这些患者的复发性胰腺炎发作.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 临床医学 临床医学
背景情况:
- 关于急性酒精性胰腺炎的胆结石发病率和临床相关性存在有限的数据.
- 了解这些因素对于预防复发性急性胰腺炎至关重要.
研究的目的:
- 为了确定疑似急性酒精性胰腺炎的患者胆结石的发病率.
- 评估胆结石和复发性急性胰腺炎之间的关联.
主要方法:
- 在23家医院 (2008-2019) 招募急性酒精性胰腺炎第一发病患者的前景.
- 通过成像检查确定了胆结石存在 (胆结石或胆管污泥).
- 主要结局:胰腺炎在3年内复发.
主要成果:
- 在分析的316名患者中,胆结石检测到17.6%的患者.
- 在患有胆结石的患者中,复发性急性胰腺炎发生在59%的患者中,而没有胆结石的患者是34.2% (P < 0.001).
- 胆囊切除术与较低的复发率相关 (P = 0.038).
结论:
- 在患有急性酒精性胰腺炎的近五分之一的患者中发现了胆结石.
- 胆结石与胰腺炎复发的风险更高有关.
- 胆囊切除似乎可以降低复发性胰腺炎的发生率.
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