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Updated: May 7, 2026

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
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Published on: January 12, 2015

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动蛋白结合蛋白CAP1抑制了小鼠大脑皮层中MRTF-SRF依赖的基因表达

Sharof Khudayberdiev1,2, Kerstin Weiss1, Anika Heinze1

  • 1Molecular Neurobiology Group, Institute of Physiological Chemistry, Philipps-University of Marburg, 35032 Marburg, Germany.

Science signaling
|May 7, 2024
PubMed
概括

环酶相关蛋白CAP1抑制大脑转录因子的活动. CAP1无活化促进MRTF的核转移,激活SRF依赖的信号传递,这对神经网络形成至关重要.

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A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

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相关概念视频

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Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
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Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...