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在绝经后妇女的阴道微生物群和阴道炎症免疫标志物之间的关联
Elizabeth H Byrne1, Hoseung Song2, Sujatha Srinivasan3
1From the Department of Obstetrics & Gynecology, Massachusetts General Hospital, Boston MA.
Menopause (New York, N.Y.)
|May 7, 2024
概括
在绝经后的个体中,较低的阴道微生物群多样性和乳酸菌的优势与减少的炎症相关. 这表明乳酸菌在绝经后的阴道免疫恒常状态上具有有益的影响.
科学领域:
- 妇科 妇科 妇科 妇科
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
背景情况:
- 阴道微生物群的多样性和缺乏Lactobacillus主导地位与增加的粘膜炎症和更高的宫发育不良和感染的风险有关,在绝经前的个人.
- 阴道微生物群和绝经后炎症之间的关系,当微生物群组成发生变化时,仍然不清楚.
研究的目的:
- 调查阴道微生物群组成和绝经后个体的免疫标志物之间的关联.
- 为了确定在绝经前的个体中关于微生物群和炎症的发现是否适用于绝经后.
主要方法:
- 一个随机试验子集的post hoc分析,涉及绝经后的个体.
- 用16S rRNA基因测序分析阴道液样本的微生物群,并通过MesoScale Discovery对免疫标记物 (细胞因子) 进行分析.
- 统计分析包括线性混合模型,主要成分分析和GLMM-MiRKAT,以探索细胞因子与微生物群多样性 (香农指数) 和主导之间的关联.
主要成果:
- 总共分析了119名绝经后的个人 (平均年龄61岁);29.5%的人在基线时具有Lactobacillus的主导地位.
- 更高的α多样性 (香农指数) 与免疫标记有显著的关联 (P = 0.003).
- 乳杆菌的优势与较低的炎症性细胞因子度有关 (例如IL-10,IL-1b,IL-6,IL-8),类似于更年期前的发现. 减少的α多样性与12周内减少的促炎性细胞因子相关 (P = 0.018).
结论:
- 在绝经后的女性中,乳酸菌的占主导地位和较低的阴道α多样性与减少的炎症免疫标志物有关.
- 这些发现表明,尽管乳酸菌的发病率较低,但即使在更年期后,乳酸菌仍然对阴道免疫均质保持有益影响.
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