提高胃癌的早期检测:一个多层次优化的特征选择模型,具有交叉信息反
Jiejun Lin1, Fangchao Zhu1, Xiaoyu Dong2
1Department of Gastroenterology, The Dingli Clinical College of Wenzhou Medical University (Wenzhou Central Hospital), Wenzhou, Zhejiang, 325000, China.
Computers in biology and medicine
|May 7, 2024
概括
这项研究提出了一种新的方法,bCIFMVO-FKNN-FS,用于早期检测胃癌 (GC). 该模型在识别早期GC患者方面取得了很高的准确性,提高了诊断能力.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 计算医学是一种计算医学.
背景情况:
- 早期发现胃癌 (GC) 对于改善患者的生存率和治疗结果至关重要.
- 目前的诊断方法可能在识别疾病的初始阶段方面存在局限性.
- 开发先进的查工具对于及时干预至关重要.
研究的目的:
- 引入和验证基于包装的创新特征选择方法,bCIFMVO-FKNN-FS,用于早期GC检测.
- 提高识别早期GC患者的准确性和效率.
- 确定与早期GC相关的关键临床参数.
主要方法:
- 开发了一个新的bCIFMVO-FKNN-FS模型,将交叉信息反多节优化器 (CIFMVO) 与模糊的k-最近邻居 (FKNN) 集成在一起.
- 在IEEE CEC基准函数上对11个最先进的算法进行验证的CIFMVO性能.
- 将bCIFMVO-FKNN-FS模型应用于诊断为早期GC或慢性胃炎的1632名患者的临床数据.
主要成果:
- CIFMVO算法在各种维度中证明了竞争优化效率.
- 对于早期GC检测,bCIFMVO-FKNN-FS模型实现了83.395%的预测准确度和87.538%的灵敏度.
- 确定了年龄,性别,血清胃素-17,血清素I和PGI/PGII比率作为早期GC的重要指标.
结论:
- 拟议的bCIFMVO-FKNN-FS模型对于早期查胃癌是有效的.
- 鉴定的临床参数为早期GC诊断提供了有价值的见解.
- 这项研究有助于开发用于及时检测和管理GC的先进工具.
相关概念视频
01:21Cancer Survival Analysis
345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K