选择性聚烯纳米塑料在胎儿大脑中的生物积累和对髓发育的损害
Yaping Zhang1, Lei Tian2, Jiang Chen3
1Tianjin Institute of Environmental and Operational Medicine, Tianjin 300050, China; School of Public Health and Management, Binzhou Medical University, Yantai 264003, China.
Ecotoxicology and environmental safety
|May 7, 2024
概括
产前暴露于聚乙烯纳米塑料 (PS-NP) 通过胎盘传输,在胎儿大脑区域积累. 这种暴露显著影响小脑髓的发育,导致后代的运动缺陷.
科学领域:
- 环境科学 环境科学
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 微纳米塑料是新兴的环境污染物,具有潜在的健康风险.
- 纳米塑料对胎儿大脑发育的影响在很大程度上是未知的.
- 了解纳米塑料的神经毒性对于评估发育风险至关重要.
研究的目的:
- 为了研究纳米塑料对胎儿大脑发育的影响.
- 为了确定纳米塑料在胎儿大脑中的分布.
- 评估纳米塑料暴露对小脑髓化的影响.
主要方法:
- 怀孕的老鼠暴露在不同度的聚乙烯纳米塑料 (PS-NP) 中.
- 分析了胎儿大脑区域中纳米塑料的分布.
- 评估了大脑小骨髓发育标志物 (MBP,MOG),小骨髓细胞数量,细胞亡和骨髓厚度.
主要成果:
- 证据表明,PS-NPs通过胎盘转移到胎儿大脑,并在小脑,海马,状体和前额叶皮层积累.
- 暴露于PS-NP显著降低了髓基本蛋白 (MBP) 和髓寡细胞糖蛋白 (MOG) 的表达.
- 观察到髓厚度的降低,细胞亡的增加和小寡细胞数量的减少,与运动缺陷相关.
结论:
- 产前接触PS-NP会导致它们在胎儿大脑的关键区域内分布.
- 在胎儿发育过程中,PS-NP抑制小脑髓的形成.
- 这种髓化抑制可以导致后代观察到的运动缺陷.
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