了解被诊断为多发性骨髓瘤的老年人的健康结果偏好
Supriya Maheshwari1, Miguel Arias1, Clare Ubersax1
1Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
Journal of geriatric oncology
|May 7, 2024
概括
患有多发性骨髓瘤 (MM) 的老年人优先考虑生活质量,功能独立性和认知能力,而不是生存. 这些发现可以为老年癌症患者提供个性化治疗目标和共享决策.
科学领域:
- 老年瘤学 老年瘤学
- 血液学 血液学 血液学
- 健康 结果 研究 研究 结果
背景情况:
- 患者在癌症治疗中对健康结果的偏好受到年龄和治疗负担的影响.
- 老年人通常对生存,生活质量和功能健康有独特的优先考虑.
研究的目的:
- 研究成年人被诊断患有多发性骨髓瘤 (MM) 的年龄和健康结果偏好之间的关联.
- 为了比较年轻 (50-69岁) 和老年 (≥70岁) 的MM成年人之间治疗结果的优先级.
主要方法:
- 对119名患有MM的成年人 (≥50岁) 进行前性队列研究,正在接受老年评估.
- 使用9项利克尔特尺度评估健康结果偏好,比较年龄组 (50-69岁与≥70岁).
- 多变量比例赔率模型用于调整诸如脆弱性和细胞遗传学之类的共变量.
主要成果:
- 与年轻人相比,老年人 (≥70) 更有可能优先考虑生活质量,功能独立,认知能力和缓解疼痛,而不是生存 (p<0.05).
- 年龄增加与优先考虑功能独立 (aOR 2.55) 和认知能力 (aOR 1.75) 的可能性更高有关.
- 年龄较大与优先考虑生存而不是生活质量的几率下降相关 (aOR 0.45) 和缓解疼痛 (aOR 0.39).
结论:
- 显著的大多数老年人 (≥70岁) 患有MM的价值功能和认知福祉超过延长生存期.
- 了解这些特定于年龄的偏好对于定制治疗目标和加强多发性骨髓瘤护理中共享决策至关重要.
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