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Updated: Jun 27, 2025

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在REM睡眠期间的内膜活动促进了恐惧的灭绝,记忆的消失

Jiso Hong¹, Kyuhyun Choi², Marc V Fuccillo²

¹Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

Current biology : CB

|May 7, 2024

概括

快速眼球运动 (REM) 睡眠辅助器害怕灭绝. 在创伤后REM睡眠期间抑制内膜皮层会损害这一过程,这表明REM睡眠对于防止创伤性记忆至关重要.

科学领域:

神经科学是一个神经科学.
睡眠科学睡眠科学
记忆研究记忆研究

背景情况:

快速眼动 (REM) 睡眠因其在处理恐惧记忆和促进恐惧灭绝中的作用而得到认可.
创伤后REM睡眠中断与患上创伤后应激障碍 (PTSD) 的风险增加有关.
通过REM睡眠支持厌恶记忆的灭绝的精确机制尚未完全理解.

研究的目的:

调查REM睡眠期间的内膜皮层 (IL) 在巩固恐惧灭绝记忆中的作用.
阐明REM睡眠对创伤性记忆的保护作用背后的神经机制.

主要方法:

成像在小鼠观察IL金字塔神经元活动在REM睡眠期间.
光遗传学操纵以抑制IL活动,特别是在REM睡眠期间在不同的时间点.
全细胞补丁录音以评估REM睡眠抑制后的神经元刺激性.

主要成果:

大多数IL金字塔神经元在REM睡眠期间显示出显著的激活.
在REM睡眠期间对IL的光遗传抑制在恐惧后4小时内影响了灭绝记忆的巩固.
在灭绝学习后的REM特异性IL抑制没有影响已建立的灭绝记忆.
在REM睡眠期间抑制IL神经元降低了它们的整体刺激能力.

结论:

在恐惧调节后的REM睡眠通过增加IL神经元刺激性来增强恐惧灭绝.
这些发现强调了REM睡眠在创伤事件发生后立即发挥的关键作用,以减轻创伤记忆的持续性.
针对REM睡眠可以为PTSD预防提供新的治疗策略.

关键词:

恐惧灭绝灭绝的恐惧快速眼睛运动 (REM) 睡眠是什么?闭环刺激的闭环刺激脑内膜下皮层的皮层.记忆的整合记忆的整合

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