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在老鼠中,Launaea fragilis提取物通过调节IL-1β,TNF-α,IL-6,NF-κB,COX-2,IL-4和IL-10来减弱关节炎
Muhammad Fiaz1, Muhammad Asif2, Kashif Ur Rehman Khan3
1Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Punjab, Pakistan.
Inflammopharmacology
|May 7, 2024
概括
里斯坦沙漠植物Launaea fragilis具有显著的抗nociceptive,抗炎和抗关节炎性质. 它的乙醇提取物在动物模型中证明了安全性和有效性,减少疼痛和炎症.
科学领域:
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
- 自然产品化学 自然产品化学
背景情况:
- 拉纳亚物种以其在治疗炎症疾病中的传统用途而闻名.
- Launaea fragilis (Asso) Pau是一种被记录的药用植物,在霍利斯坦沙漠中发现.
研究的目的:
- 研究Launaea fragilis (Et-LF) 的乙醇提取物的抗nociceptive,抗炎和抗关节炎潜力.
主要方法:
- 使用GC-MS的植物化学查确定了诸如n-tetracosanol-1和n-hexadecanoic acid等关键化合物.
- 在体内研究评估了镇痛效应 (热板,酸曲),抗炎活性 (胀模型) 和抗关节炎效应 (CFA诱导的关节炎模型).
- 进行了基因表达分析 (IL-1β,TNF-α,IL-6,NF-κB,COX-2,IL-4,IL-10) 和组织学评估.
主要成果:
- Et-LF表现出显著的止痛作用和剂量依赖的脚胀抑制.
- 提取物减轻了脚的胀,改善了体重,并使关节炎小鼠的血液学参数正常化.
- Et-LF调节炎症基因表达和减轻关节损伤,包括形和炎症细胞透.
结论:
- 拉纳亚脆弱的乙醇提取物具有显著的抗nociceptive,抗炎和抗关节炎活动.
- 这些治疗作用归因于植物提取物中存在各种生物活性植物成分.
- Et-LF代表了一种有前途的天然治疗剂,用于炎症和与疼痛相关的疾病.
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