由于达9-四化卡纳比诺的中毒,其特点是前额叶皮层活动受到干扰
Keerthana Deepti Karunakaran1,2, Michael Pascale1, Nisan Ozana3,4
1Massachusetts General Hospital (MGH) Department of Psychiatry, Boston, MA, USA.
概括
急性大麻中毒会破坏前额叶皮层 (PFC) 的大脑活动. 德尔塔-9-四大麻 (THC) 降低了PFC中的功能连接和改变了神经动态,可能解释了认知障碍.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 脑部成像 脑部成像
背景情况:
- 大麻中毒的神经机制尚不清楚.
- 前额叶皮层 (PFC) 对于认知功能至关重要,是 Δ9-四大麻素 (THC) 的首要目标.
研究的目的:
- 调查急性THC中毒对PFC静止状态功能连接 (RSFC) 的影响.
- 在中毒期间评估PFC中神经动态和光谱功率的变化.
主要方法:
- 这是一项双盲,随机,交叉研究,涉及常规大麻使用者.
- 单独剂量的THC或安慰剂的口服.
- 使用便携式功能近红外光谱 (fNIRS) 评估PFC活动.
主要成果:
- THC增加了主观中毒和心率.
- 在PFC中,THC降低了静态RSFC,更大的干扰与更高的中毒严重程度相关.
- THC增加了动态RSFC变异性,并减少了PFC中的光谱功率.
结论:
- 急性THC中毒会破坏PFC神经动态,包括功能连接和光谱功率.
- 这些神经变化可能是THC的认知损伤影响的基础.
- 便携式fNIRS可以检测到PFC中的THC诱导的神经变化.
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