在儿童中传播的普通感冒病毒通过无症状的成年携带者威胁到野生黑猩猩
Taylor E Weary1, Tressa Pappas2, Patrick Tusiime3
1Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, WI, USA.
Scientific reports
|May 7, 2024
概括
成年人可能无症状地将普通感冒病毒从儿童携带到森林,对黑猩猩构成风险. 针对有症状的成年人的干预措施不太可能防止将反向动物性传染病传播给大猿.
科学领域:
- 生态学和进化生物学
- 流行病学 流行病学
- 保护生物学 保护生物学
背景情况:
- 反向动物传染病是由人类病原体传播给动物引起的,对撒哈拉以南非洲的大猿构成重大威胁.
- 人类呼吸道病毒,特别是普通感冒病原体,与野生黑猩猩的疫情有关,但传播途径尚不清楚.
研究的目的:
- 研究人类呼吸道病毒从社区传播到乌干达野生黑猩猩的传播途径.
- 确定儿童和成人在这些病原体的循环和潜在传播中的作用.
主要方法:
- 一项前性队列研究,涉及234名儿童和30名乌干达基巴莱国家公园附近的森林工作成年人 (2019年5月至2021年8月).
- 收集呼吸道症状调查和鼻抽样,用于人类的多重病毒诊断.
- 从野生黑猩猩收集便样本,以检测病原体和评估疾病爆发.
主要成果:
- 儿童的呼吸道感染率高于成年人;COVID-19封锁在两个人群中减少了发病率.
- 犀牛病毒是最常见的人类病原体,全年循环,成年人无症状携带.
- 在锁定后,在黑猩猩中检测到与人类菌株遗传上相似的人类甲型肺炎病毒,这表明最近的传播.
结论:
- 呼吸道病毒主要在儿童中传播,成年人无症状携带.
- 无症状的成年人可能充当载体,将病原体引入黑猩猩群体.
- 干预策略只关注有症状的成年人是不够的,以防止对黑猩猩的逆转动物传播.
更多相关视频
10:39Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity
Published on: June 25, 2015
12.6K
09:07Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
Published on: January 20, 2017
9.9K
相关概念视频
Viral Recombination
23.4K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.4K
Viral Mutations
32.3K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.3K
Infection
7.9K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.9K
Cross-reactivity
31.0K
Overview
31.0K
Vaccinations
44.4K
Overview
44.4K
