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Updated: Jun 27, 2025

Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules
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Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules

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哺乳动物IRE1α在动态和功能上与应力颗粒结合

Songzi Liu1, Xiaoge Zhang1, Xin Yao1

  • 1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences; TaiKang Center for Life and Medical Sciences; the Institute for Advanced Studies; Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China.

Nature cell biology
|May 7, 2024
PubMed
概括

细胞内膜网膜 (ER) 的压力触发了需要内醇的酶1 (IRE1) 通过相分离与压力颗粒 (SG) 聚合. 这种IRE1-SG凝结物形成在细胞应激过程中增强了支持生存的X盒结合蛋白1 (XBP1) 途径.

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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The Unfolded Protein Response01:37

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