综合性泛癌分析炎症与年龄钟相关的基因作为预后和免疫标志物,基于多omics数据
Bo Yan1,2, Pan Liao2,3, Shan Liu1,2
1Haihe Laboratory of Cell Ecosystem, Department of Geriatrics, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Scientific reports
|May 7, 2024
概括
与年龄相关的炎症基因 (iAge-CRG),特别是DCBLD2,与癌症进展和免疫反应有关. 一个五个基因的签名显示了预测皮膜黑色素瘤 (UVM) 预后和增强免疫治疗的希望.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 慢性炎症和衰老影响癌症的发展.
- 在各种癌症中,炎症性年龄时钟相关基因 (iAge-CRGs) 的作用在很大程度上尚未被探索.
- 了解iAge-CRG可以揭示新的治疗点和预后标志物.
研究的目的:
- 研究iAge-CRG在33种癌症类型中的机制和临床应用.
- 探索DCBLD2在单细胞癌症中的特定作用.
- 为癌症患者开发基于iAge-CRG的预后签名.
主要方法:
- 分析了来自33种癌症类型的1万多名患者的多组数据.
- 使用基因组变异分析 (GSVA) 计算iAge-CRG得分.
- 使用考克斯和LASSO回归的预后签名的开发,通过ROC分析,名录和决策曲线分析进行验证.
主要成果:
- 在iAge-CRG中发现了表观遗传,基因组和免疫基因组的改变,特别是DCBLD2.
- 异常的DCBLD2表达与癌症相关的纤维细胞透和多种癌症的更差预后相关.
- 一个五基因的iAge-CRG风险模型作为皮膜黑色素瘤 (UVM) 患者的独立预后指数.
结论:
- iAge-CRG,特别是DCBLD2,与癌症的发展和免疫抑制有关.
- DCBLD2的异常表达是各种癌症中显著的预后因素.
- 开发的五个基因签名为UVM预后提供了有价值的工具,并可能指导免疫治疗策略.
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