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Updated: Jun 27, 2025

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改善的CAR-T细胞活动与增加的线粒体功能相关,由银河糖为原料.

Golda Gross1,2, Suha Alkadieri1,2, Amilia Meir1

  • 1Cell Therapy Lab, Sheba Medical Center, Tel Hashomer, Israel.

Leukemia
|May 7, 2024
PubMed
概括

用银河糖增强CAR-T细胞代谢可以改善线粒体功能,并提高白血病模型中的疗效. 这种代谢转变为在癌症治疗中克服CAR-T细胞复发提供了一个有希望的策略.

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Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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