利多卡因对经历大血管手术的患者手术后血压变化的影响
Dariusz Gajniak1, Konrad Mendrala2, Gabriela König-Widuch3
1Department of Anaesthesiology and Intensive Care, Upper-Silesian Medical Centre of the Medical University of Silesia in Katowice, Ziolowa 45 street, Katowice, 40-635, Poland. darekgajniak@wp.pl.
BMC anesthesiology
|May 7, 2024
概括
静脉注射利多卡因在接受重大血管手术的患者中没有改变手术内血压变化 (BPV). 这项研究发现,在这些过程中,利多卡因和安慰剂组之间的BPV指标没有显著差异.
科学领域:
- 麻醉学 麻醉学
- 心血管外科心血管外科
- 药理学 药理学 是一个学科.
背景情况:
- 动态的动脉血压波动,称为血压变化 (BPV),可以产生短期和长期的不良影响.
- 术内BPV评估是常见的,但其对患者结果的意义仍在争论中.
- 利多卡因除了具有抗心律不良的特性之外,还具有心血管作用.
研究的目的:
- 研究静脉注射利多卡因对手术期间血压变化 (BPV) 的影响.
- 在全身麻醉下进行重大血管手术的患者中评估BPV.
主要方法:
- 对一项随机临床试验的后期分析,该试验涉及接受选择性腹腔大动脉和/或腹腔动脉手术的患者.
- 患者在全身麻醉期间接受了静脉注射利多卡因或安慰剂输液.
- 在5分钟间隔记录了静脉血压的静脉血压,静脉血压和平均动脉血压,并使用标准偏差,变化系数,平均真实变化和血液动力稳定系数计算了BPV.
主要成果:
- 在利多卡因和安慰剂组之间没有观察到任何计算的血压变化指数的显著差异.
- 静脉血压标准偏差的具体值为20.17 (利多卡因) 和19.28 (安慰剂).
- 在手术类型,持续时间或服用其他药物和液体方面没有发现差异.
结论:
- 静脉输注利多卡因在全身麻醉下对高风险血管外科手术患者的动脉血压变化没有影响.
- 这些发现表明,在这些特定的手术过程中,利多卡因并不能显著调节血液动力稳定性.
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