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Updated: Jun 27, 2025

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来自非洲祖先的APOL1风险基因型显示出近位表观遗传关联

Charles E Breeze1, Bridget M Lin2, Cheryl A Winkler3

  • 1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. charles.breeze@nih.gov.

BMC genomics
|May 7, 2024
PubMed
概括

在阿波利波蛋白L1 (APOL1) 中的遗传变异增加了非洲祖先脏疾病的风险. 在APOL1风险变体附近的DNA甲基化变化可能解释不同的疾病严重程度.

关键词:
在APOL1风险变体中.通过DNA甲基化.慢性脏疾病 慢性脏疾病这是表观遗传学.基因调节 基因调节 基因调节甲基化定量特征位置 (meQTL)

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