在接受治愈切除术的非转移性直肠癌患者中,暂时性口腔不关闭的预测因素:回顾性分析
Chia-Chien Hsu1, Wen-Sy Tsai2,1, Tzong-Yun Tsai2
1College of Medicine, Chang Gung University, Taoyuan, Taiwan.
World journal of surgical oncology
|May 7, 2024
概括
预测直肠癌手术后的口腔非关闭是至关重要的. 晚年,动脉漏和高CEA水平是关键的危险因素,使得患者的预后和手术规划更好.
科学领域:
- 结肠直肠手术 结肠直肠手术
- 手术瘤学手术瘤学
- 预测模型在医学中的预测模型.
背景情况:
- 对于直肠癌的低前切除可以导致口腔复杂症.
- 静脉口腔的非闭合对于接受关节保护手术的患者来说是一个重大挑战.
研究的目的:
- 开发一个预测模型,用于直肠癌患者的口腔非闭合.
- 确定关键的风险因素,与暂时静脉口腔不关闭的低前切除后.
主要方法:
- 对956名非转移性直肠癌患者进行了低前切除的回顾性分析.
- 多变量分析,以确定术前风险因素,以确定静脉口腔不关闭的原因.
- 开发和验证一个风险评估模型.
主要成果:
- 10.3%的患者经历了口腔管不关闭,主要是由于复发或静脉管问题.
- 确定了重要的风险因素:晚年,解剖学性泄漏,结节状况,高CEA,下直肠瘤位置,边缘参与和低EGFR.
- 预测模型的AUC为0.724;风险评分>2.5表明非关闭率较高 (16.6%与3.7%相比).
结论:
- 晚年,静脉漏,节点状况,高CEA,边缘参与和低EGFR是静脉非关闭的关键预后因素.
- 外科医生应该评估这些因素,以提供准确的预后.
- 预测模型有助于患者咨询和手术决策.
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