脱化酶:瘤微环境的潜在调节者以及对免疫逃避的影响
Sheng-Kai Hsu1, Chon-Kit Chou2, I-Ling Lin3
1Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
Cell communication and signaling : CCS
|May 7, 2024
概括
脱化酶 (DUBs) 调节蛋白质稳态,并与癌症有关. 向瘤微环境中的DUB,通过调节免疫反应,为癌症免疫治疗提供了一个有希望的策略.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 癌症生物学 癌症生物学
背景情况:
- 翻译后的修改,包括由二氧化酶 (DUB) 进行的泛化和二氧化化,对于蛋白质平衡至关重要.
- DUBs的失调与各种疾病有关,尤其是癌症.
- 瘤微环境 (TME),一个由非癌细胞和细胞外基质组成的复杂环境,显著影响瘤发生和免疫逃逸.
研究的目的:
- 综合审查DUBs参与TME内部的动态相互作用.
- 阐明失调的DUBs如何导致免疫逃避和瘤进展.
- 总结针对癌症免疫治疗的DUBs的小分子,并讨论未来的前景.
主要方法:
- 文献综述侧重于DUBs,TME和癌症免疫学.
- 对DUBs在TME内的免疫调节中的作用进行新兴研究的分析.
- 针对DUBs的小分子抑制剂信息的综合.
主要成果:
- DUBs在TME内的免疫调节中发挥着重要作用,影响免疫检查点和免疫细胞功能.
- 功能障碍的DUBs可以通过促进免疫逃避来促进瘤的进展.
- 向DUBs为缓解免疫抑制和抑制瘤生长提供了潜在的治疗途径.
结论:
- DUBs是瘤微环境中的关键调节者,影响癌症进展和免疫逃避.
- 准DUB对开发新型癌症免疫疗法具有前景.
- 需要进一步的研究来应对挑战,并探索DUB向治疗的全部潜力.
关键词:
细胞毒性T细胞 (CTL) 是一种脱多化酶 (DUBs) 是一种脱多化酶.免疫逃避是免疫逃避的一种方式.后翻译修改 (PTM) 是指翻译后的修改.监管性T细胞 (Treg) 是一种T细胞.瘤微环境 (TME) 是指瘤的微环境.与瘤相关的巨细胞 (TAM)更多相关视频
10:25Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
Published on: November 22, 2024
257
11:36In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
Published on: July 25, 2019
10.7K
相关概念视频
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
01:15Receptor Downregulation in MVBs
2.1K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.1K
01:27Tumor Immunotherapy
518
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
518
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
01:13The Proteasome
830
Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
830
01:10Drugs that Destabilize Microtubules
2.0K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.0K