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Updated: Jun 27, 2025

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
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Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

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SGLT1和SGLT2抑制,循环代谢物和大脑小血管疾病:一个调解门德尔随机化研究

Yanchen Lv1,2, Xin Cheng3, Qiang Dong3

  • 1Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China. lvyanchenfudan@163.com.

Cardiovascular diabetology
|May 7, 2024
PubMed
概括

-葡萄糖共运输体2 (SGLT2) 和SGLT1抑制剂对大脑小血管疾病 (CSVD) 具有保护作用. 通过影响特定代谢物,SGLT2抑制降低了中风风险,并改善了白质完整性.

关键词:
大脑小血管疾病大脑小血管疾病在循环中的代谢产物.门德尔的随机化-葡萄糖共运输体1的抑制-葡萄糖共运输体2的抑制

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Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
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Secondary Active Transport01:32

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One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
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Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
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