由Streptococcus suis多血清型自身疫苗诱导的免疫反应,用于母猪保护断奶后的小猪
Alison Jeffery1, Mélina Gilbert1, Lorelei Corsaut1
1Swine and Poultry Infectious Diseases Research Centre, and Research Group On Infectious Diseases in Production Animals, Faculty of Veterinary Medicine, University of Montreal, St-Hyacinthe, QC, J2S 2M2, Canada.
Veterinary research
|May 7, 2024
概括
在母猪中对Streptococcus suis的自身疫苗改善了母猪对小猪的抗体转移,但没有预防疾病或减少细菌分泌. 需要对临床保护进行进一步评估.
科学领域:
- 兽医免疫学 兽医免疫学
- 猪的传染病 猪的传染病
- 细菌学 细菌学是一门学科.
背景情况:
- 瑞士杆菌在全球猪肉行业造成重大经济损失.
- 由于缺乏商业疫苗,因此需要为小猪提供替代的保护策略.
- 自生疫苗提供了一个潜在的解决方案,但生产在制造商之间有所不同.
研究的目的:
- 评估一种针对S. suis血清型2,1/2,5,7和14的自生疫苗,用于.
- 评估母猪的抗体反应和对小猪的被动抗体转移.
- 为了确定疫苗接种对细菌散射和潜在的临床保护的影响.
主要方法:
- 在分娩前,在三剂量治疗方案中,给子施用了一种含有特定S. suis血型的自身疫苗.
- 在母猪和它们的小猪身上测量了抗体水平.
- 在整个研究过程中,监测了母猪和小猪的细菌分泌.
主要成果:
- 接种母猪的疫苗导致抗体水平增加,并改善了母猪对小猪的抗体转移,直到5周大.
- 尽管增强了被动免疫力,但小猪在幼儿园时期晚些时候仍然容易感染S. suis病.
- 接种疫苗并没有改变母猪或小猪的S. suis脱落.
结论:
- 自生疫苗可以增强小猪的被动免疫力,但可能不会对S. suis病提供完全的保护.
- 需要进行进一步的研究,以充分评估黄金/种植疫苗接种计划的临床保护疗效.
- 自生疫苗生产的标准化和全面的临床评估对于有效的疾病控制至关重要.
更多相关视频
08:13Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination
Published on: January 20, 2019
21.6K
05:52Author Spotlight: Induction of Experimental Endotoxemic Shock in Pigs for Studying Hemodynamic and Respiratory Failure
Published on: December 8, 2023
936
相关概念视频
Vaccinations
Overview
Immunological Memory
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Vaccines
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
