在多发性硬化症中与伴随性焦虑相关的焦虑的多基因责任
Kaarina Kowalec1,2, Arvid Harder2, Casandra Dolovich3
1Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
Annals of clinical and translational neurology
|May 8, 2024
概括
对焦虑的更高遗传风险与多发性硬化症 (MS) 的焦虑症状增加有关. 这表明MS患者焦虑的遗传基础,影响疾病的进展.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 伴随性焦虑在多发性硬化症 (MS) 中普遍存在,并与残疾进展有关.
- 多基因分数 (PS) 可以预测焦虑风险,但需要在不同人群中进行验证.
- 在MS中调查泛性焦虑障碍2项尺度PS对于理解焦虑病因至关重要.
研究的目的:
- 评估MS个体中泛性焦虑障碍2项级多基因得分和焦虑之间的关联.
- 确定对焦虑的遗传倾向是否是MS患者焦虑发展的重要因素.
主要方法:
- 采用了病例控制研究设计,包括来自加拿大,英国生物库和美国队列的参与者.
- 个人被分为病例 (伴随性焦虑的MS) 和对照 (无焦虑的MS,或无免疫疾病的焦虑,或健康的对照).
- 使用当前症状,终身访谈诊断和终身自我报告医生诊断来测量焦虑;PS被计算为当前焦虑症状.
主要成果:
- 这项研究分析了71,343名欧洲遗传祖先的个人.
- 多遗传性得分的1-SD增加与MS患者中适度焦虑症状的几率增加约50%有关 (OR: 1.47,95%CI: 1.09-1.99).
- 在不同的焦虑指标中观察到类似的趋势,表明MS中焦虑的基因负担与焦虑为主要疾病的个体相似.
结论:
- 增加对焦虑的遗传倾向显着与MS患者中中度焦虑症状的几率增加有关.
- 在MS中焦虑的遗传负担与焦虑和没有伴随性免疫疾病的个体的遗传负担相似.
- 这些发现表明,在多发性硬化症中的焦虑背后有一个显著的遗传成分.
相关概念视频
01:30Generalized Anxiety Disorder
128
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
128
01:18Anxiety: Overview
265
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
265
01:28Social Anxiety Disorder
33
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
33
01:28Human Genetics
561
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
561
01:27Panic Disorder
106
Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
106
01:30Stress and Mental Health
119
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
119