将"冷"转换为"热":表观遗传学的策略通过调节与瘤相关的免疫抑制细胞来改善免疫治疗效果
Yijia Tang1, Guangzu Cui1, Haicong Liu1
1Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Cancer communications (London, England)
|May 8, 2024
概括
免疫抑制细胞 (ISC) 的表观遗传调节提供了一种新的策略,可以将不响应免疫治疗的"冷"瘤转化为"热"瘤. 这种方法可能会提高癌症治疗的疗效.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 免疫疗法已经彻底改变了癌症治疗,但许多患有恶性瘤的患者仍然没有反应.
- "冷"瘤缺乏免疫原性,并且抵抗免疫疗法,与免疫疗法不同.
- 免疫抑制细胞 (ISCs),包括瘤相关巨细胞 (TAMs),髓质衍生抑制细胞 (MDSCs) 和调节性T细胞 (Tregs),抑制抗瘤免疫反应,并与瘤相关.
- 瘤微环境 (TME) 在治疗反应中起着至关重要的作用,ISC功能障碍导致治疗不敏感.
研究的目的:
- 研究ISC在TME中的作用及其对免疫治疗反应的影响.
- 探索表观遗传机制在调节ISCs中的参与.
- 总结一下表观遗传药物如何可能将免疫疗法不敏感的瘤转化为敏感的瘤.
主要方法:
- 对ISCs,TME,表观遗传学和癌症免疫疗法的现有文献的审查.
- 分析ISCs在调节瘤免疫性方面的功能作用.
- 检查影响ISC功能的表观遗传调节途径.
主要成果:
- 高透ISC与瘤免疫性降低相关,是特征性瘤免疫性.
- 表观遗传机制是TME内部ISC功能和差异化的关键调节者.
- 通过表观遗传调制准ISC是一种有前途的策略,可以克服免疫疗法耐药性.
结论:
- 在TME中功能障碍的ISC是免疫治疗耐药性的关键贡献者.
- 对ISC的表观遗传重编程具有转化转化潜力.
- 通过表观遗传药物调节ISC代表了一种创新的治疗途径,用于提高在患者体内免疫疗法的疗效.
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