通过分子内静电锁解锁NIR-II AIEgen以获得高亮度
Xinyuan Wang1,2, Xueqin Yang2, Guanyu Jiang3
1Department of Materials Science and Engineering, Shenzhen Key Laboratory of Printed Organic Electronic, Southern University of Science and Technology, Shenzhen, 518055, China.
Angewandte Chemie (International ed. in English)
|May 8, 2024
概括
研究人员使用分子内静电锁开发了更明亮的近红外II (NIR-II) 聚合诱导发射 (AIE) 光体. 这一策略增强了光,改善了血管和瘤成像,并在诊断试验中检测敏感抗原.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 化学生物学 化学生物学
背景情况:
- 近红外II (NIR-II) 窗口成像提供非侵入性,无辐射的诊断.
- 开发明亮的NIR-II光体仍然是临床应用的重大挑战.
研究的目的:
- 为了增强NIR-II聚合诱发发射 (AIE) 光体的亮度.
- 探索分子内静电锁作为AIE光增强亮度的策略.
- 为了评估这些增强的光体在体内成像和生物传感中的潜力.
主要方法:
- 通过将硫原子引入蒂奥芬桥侧链,合成了一种新的TSEH分子.
- 研究了分子内相互作用以锁定结合的脊柱的分子运动.
- 封装TSEH分子成纳米粒子 (NP) 和聚烯纳米球用于应用测试.
主要成果:
- 在溶液和聚合状态下,TSEH分子表现出增强的NIR-II光辐射.
- 与对照组相比,TSEH NPs显示亮度增加了2.6倍.
- 在体内研究显示了血管和瘤成像的可行性,其信号与背景比率高.
- 使用TSEH封装的纳米圈进行的侧向流量测试显示,抗原检测的信号噪声比高1.9倍.
结论:
- 内分子静电锁是开发明亮NIR-II AIE光体的有效策略.
- 开发的TSEH光体显示出先进的临床诊断和生物医学研究的巨大潜力.
- 这项工作为新型NIR-II成像剂和诊断工具铺平了道路.
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