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基异硫酸盐改善了慢性叶的小鼠的认知功能
Chang Xiaoyu1,2, Zhou Hongzhen3, Peng Nan3,4
1School of Public Health and Management, Ningxia Medical University, Yinchuan, China.
Frontiers in neurology
|May 8, 2024
概括
基异硫酸 (BITC) 在患有叶的小鼠中改善了认知功能和运动能力. BITC通过减少氧化应激和增强抗氧化能力来证明神经保护作用.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生化学
背景情况:
- 叶 (TLE) 是一种常见的,与认知缺陷相关的耐药性.
- 氧化压力与TLE病变发生,神经退行和认知功能障碍有关.
- 基异硫酸 (BITC) 具有已知的抗氧化和神经保护性质.
研究的目的:
- 为了研究BITC在-皮洛卡尔诱导的TLE小鼠模型中的神经保护作用.
- 评估BITC对认知功能,运动活动和中氧化应激标志物的影响.
主要方法:
- 使用Intellicage,莫里斯水迷宫,开放场地和被动回避测试来评估认知和运动功能.
- 通过Nissl染色来评估神经保护,并使用qPCR测量Nrf2,HO-1和NQO1的基因表达.
- 氧化应激标志物,包括MDA,SOD,GSH-Px和T-AOC,被量化.
主要成果:
- 在性小鼠中,BITC治疗改善了认知和运动性能.
- 引起CA3区域的神经元损失,BITC治疗减轻了这种损失,特别是在皮层.
- BITC的使用可提高Nrf2,HO-1和NQO1的表达,增加GSH-Px活性,并降低MDA水平,表明氧化应激降低.
结论:
- 在TLE小鼠模型中,BITC有效地改善了认知障碍.
- BITC的神经保护作用归因于其抗氧化特性和关键抗氧化途径的调节.
- BITC显示出作为治疗性植物化学物质的潜力,用于管理与有关的认知功能障碍.
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