瘤负担会影响索拉芬尼布治疗患者的预后进展模式
Jun Sun1, Dongdong Xia1,2, Wei Bai1,2
1Department of Liver Disease and Digestive Interventional Radiology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, Shaanxi, China.
Frontiers in oncology
|May 8, 2024
概括
瘤进展模式显著影响晚期肝细胞癌 (HCC) 的存活率. 肝外进展恶化了结果,特别是较低的瘤负担,指导个性化治疗策略.
科学领域:
- 肝胆瘤学 肝胆瘤学
- 癌症进展研究 癌症进展研究
- 临床试验设计 临床试验设计
背景情况:
- 瘤进展模式影响晚期肝细胞癌 (HCC) 的存活率.
- 之前关于HCC进展模式和存活率的研究已经产生了矛盾的结果.
- 了解这些模式对于临床试验设计和患者预后至关重要.
研究的目的:
- 分析不同瘤进展模式和瘤负担对HCC患者存活率的影响.
- 研究HCC中进展模式和瘤负担之间的相互作用.
- 为个人化治疗和HCC的临床试验设计提供见解.
主要方法:
- 对538名接受索拉费尼布治疗的HCC患者进行了回顾性队列研究,并显示了放射性进展.
- 考克斯回归分析包括进展模式和瘤负担之间的相互作用术语.
- 使用六和十二个标准将瘤负担分为低,中,高的子组.
主要成果:
- 与肝外进展 (NIH/IHG) 患者相比,肝外进展 (NEH/EHG) 患者的整体存活率 (OS) 和进展后存活率 (PPS) 显著降低.
- 肝外进展的危险比率在低瘤负担 (HR 2.729) 时最高,并且随着瘤负担的增加而下降.
- 具体来说,肝内进展的OS为14.1/19.9个月,肝外进展为9.3/9.2个月;PPS为8.1/13.1个月,肝外进展为4.9/5.1个月.
结论:
- 瘤进展模式和瘤负担之间的相互作用显著影响HCC患者的预后.
- 随着瘤负担的增加,患者的死亡风险对特定的进展模式变得不那么敏感.
- 这些发现对于优化个性化治疗策略和完善HCC临床试验设计非常有价值.
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