早期血管栓塞可以改善脑内动脉瘤患者的神经功能
Tiezhu Guo1, Zhenfen Cui1, Jianhong Li1
1Department of Neurosurgery, Heji Hospital Affiliated to Changzhi Medical College Changzhi 046000, Shanxi, China.
American journal of translational research
|May 8, 2024
概括
在内动脉瘤的早期血管栓塞改善了结果. 这种方法增强神经功能,并减少炎症标记物矩阵金属蛋白酶-9 (MMP-9) 和核因子-kappa B (NF-κB),从而导致更好的预后.
科学领域:
- 神经学 神经学
- 血管外科 血管外科
- 生物医学工程 生物医学工程
背景情况:
- 内动脉瘤带来重大风险,及时干预对于患者的治疗结果至关重要.
- 炎症标志物如矩阵金属蛋白酶-9 (MMP-9) 和核因子-卡帕B (NF-κB) 在动脉瘤进展和神经功能中的作用是一个正在进行的研究领域.
研究的目的:
- 评估早期血管栓塞与延迟血管栓塞在治疗内动脉瘤的疗效.
- 研究栓塞时间对神经功能和炎症标志物 (MMP-9和NF-κB) 的影响.
主要方法:
- 对90名内动脉瘤患者的回顾性分析,分为早期 (72小时内) 和延迟 (72小时后) 栓塞组.
- 两组之间的完全栓塞率,术后并发症,神经功能 (修改的巴特尔指数),MMP-9和NF-κB的血清和蛋白质水平以及3个月的预后的比较.
- 所有患者都接受了手术后的抗血小板治疗 (克洛皮多格雷尔二硫酸盐和肠涂层阿司匹林).
主要成果:
- 早期栓塞组的完全栓塞率 (90.70%) 与延迟栓塞组 (72.34%) 相比较高.
- 在早期组 (9.30%) 与延迟组 (27.66%) 相比,术后并发症显著降低.
- 在早期栓塞组中观察到神经功能改善和MMP-9和NF-κB的血清/蛋白质水平降低.
结论:
- 早期血管栓塞是内动脉瘤的有效治疗方法.
- 这种方法导致了更好的神经恢复和减少炎症.
- 早期干预与内动脉瘤患者的预后更为有利.
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