相关实验视频
Updated: Jun 27, 2025

Porcine Model of Infrarenal Abdominal Aortic Aneurysm
Published on: November 21, 2019
在患有上升性大动脉动脉瘤患者使用Pembrolizumab的预防性说明
Muhammad E A Khan1, Shane Ahern1, Sophie C Prendergast2
1Department of Cardiothoracic Surgery, Cork University Hospital, Cork, Ireland.
免疫检查点抑制剂,如 pembrolizumab,可以导致由于主动脉炎导致主动脉动脉瘤迅速扩张. 患有先前存在的动脉瘤的患者需要在此疗法期间保持警的监测.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 正在彻底改变癌症治疗.
- 动脉炎是ICI的新出现的不良影响,呈现方式各异.
- 患有先前存在的大动脉动脉瘤的患者可能面临更高的风险.
研究的目的:
- 报告一例pembrolizumab诱导的上升大动脉动脉瘤扩张的病例.
- 突出ICI相关的风炎的潜力在患有先前存在动脉瘤的患者中.
- 强调在这种情况下需要仔细监视.
主要方法:
- 一个患有转移性头皮黑色素瘤的病人用 pembrolizumab 接受治疗的病例报告.
- 详细的临床病史,成像和对大动脉动脉瘤进行手术的干预.
- 切除的大动脉组织的组织病理学分析.
主要成果:
- 这位患者已经发展了先前存在的上升大动脉动脉瘤的快速扩张.
- 组织学揭示了炎症性主动脉炎,与ICI诱导的机制一致.
- 需要进行手术来治疗动脉瘤.
结论:
- 布罗利祖马布可以诱导炎症性主动脉炎,导致主动脉动脉瘤扩张.
- 已知的大动脉动脉瘤患者在ICI治疗时需要密切监测.
- 在这种情况下,早期考虑干预选择对于管理动脉瘤扩张至关重要.
更多相关视频
10:09Drug Treatment by Central Venous Catheter in a Mouse Model of Angiotensin II Induced Abdominal Aortic Aneurysm and Monitoring by 3D Ultrasound
Published on: August 4, 2022
06:46Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection
Published on: July 16, 2018
相关概念视频
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...